Areas of Research
Immuno-Modulation
Allergies
Degenerative Conditions
Epinephrine/Dopamine Regulation
Neuronal Antioxidant (Stroke, TBI, Memory)
Vitamin C and Liposomal Technology Vitamin C has multiple beneficial physiological effects. These include antioxidant properties, synthesis of catecholamines, formation of collagen, facilitation of iron absorption, and support with the processing of many hormones, enzymes, and amino acids. In a recent clinical study, it was demonstrated that oral delivery of Liposomal Vitamin C produced circulating concentrations of vitamin C greater than those elicited by oral delivery of Non-Liposomal Vitamin C and has the added ability to cross through the Blood Brain Barrier. [1] [2]
Immuno-Modulation Vitamin C affects various aspects of the immune process. Its high concentration in leukocytes, its rapid utilization during infection, and its depression in clinical situations associated with reduced immunologic function have suggested a role for the vitamin in the immune response. There is evidence that Vitamin C is involved in several neutrophil functions, including chemotactic responses, phagocytosis, hexose monophosphate shunt activity, myeloperoxidase function, and cyclic GMP levels. [3]
Degenerative Conditions Research suggests that high-dose vitamin C kills degenerative cells. New studies show some degenerative cells with low levels of catalase enzyme activity are much less capable of removing hydrogen peroxide formed by vitamin C, than normal cells, and are more susceptible to damage and death when they are exposed to high doses of vitamin C. [4]
Norepinephrine/Dopamine Regulation Vitamin C functions as a neuromodulator for dopamine and norepinephrine. A deficiency of Vitamin C is associated with significant increases in dopamine levels and similar relative decreases in norepinephrine because normal amounts of dopamine could not be metabolized into norepinephrine. Liposomal Vitamin C is capable of crossing the blood-brain barrier to regulate dopamine and nor-epinephrine levels. [5]
Neuronal antioxidant support Studies show Vitamin C is a vital antioxidant. Vitamin c has shown promise in its high antioxidant role against ischemic stroke, Alzheimer's disease, Parkinson's disease, and Huntingdon's disease. [5]
Stroke Several studies found that a low vitamin C status in humans is associated with increased mortality rates from stroke, and plasma Vitamin C concentrations are decreased in stroke and critically ill patients. This data on antioxidant depletion suggests that there is significant oxidative stress associated with brain injury. [6]
Post Traumatic Stress Disorder (PTSD) Oxidative stress is linked with many psychiatric conditions including PTSD. Vitamin C has successfully attenuated memory impairment and all changes observed in oxidative stress markers induced by PTSD. [7]
Traumatic brain injury (TBI) TBI is an acquired brain injury that occurs when there is sudden trauma that leads to brain damage. There is evidence that a secondary injury from TBI is specifically related to oxidative stress. By incorporating antioxidant support with Vitamin C, clinicians can help attenuate oxidative posttraumatic brain damage and optimize patients' recovery. [8]
Memory In a recent study vitamin C administration successfully attenuated memory impairment and all of the changes observed in oxidative stress markers. Oxidative stress is associated with neuronal damage in many brain regions including the hippocampus; an area in the brain responsible for memory processing. [7]
Ingredients: Ascorbate Acid (Vitamin C), Sodium Ascorbate, Potassium Sorbate, Stevia Leaf Extract (as Glucosylsteviosides), Natural Flavors, Glycerin, Non-GMO Sunflower Lecithin, Purified Water.
Sources: [1] J. L. Davis, H. L. Paris, J. W. Beals, S. E. Binns, G. R. Giordano, R. L. Scalzo, M. M. Schweder, E. Blair and C. Bell, "Liposomal-encapsulated Ascorbic Acid: Influence on Vitamin C Bioavailability and Capacity to Protect Against Ischemia–Reperfusion Injury," Nutr Metab Insights, vol. 9, pp. 25-30, 2016. [2] "Vitamin C Shown To Cross The Blood Brain Barrier," Memorial Sloan-Kettering Cancer Center, 6 December 1997, sciencedaily.com/releases/1997/12/971206133607.htm. [Accessed 10 May 2022]. [3] B. V. Siegel, "Vitamin C and the Immune Response in Health and Disease," Nutrition and Immunology, pp. 167-196, 1993. [4] C. M. Doskey, V. Buranasudja, B. A. Wagner, J. G. Wilkes, J. Du, J. J. Cullen and G. R. Buettner, "Why high-dose vitamin C kills cancer cells: Low levels of catalase enzyme make cancer cells vulnerable to high-dose vitamin C.," Redox Biology, vol. 10, no. 274, 2016. [5] F. E. Harrison and J. M. May, "Vitamin C Function in the Brain: Vital Role of the Ascorbate Transporter (SVCT2)," Free Radic Biol Med, vol. 46, no. 6, pp. 719-730, 2009. [6] M. C. Polidori, P. Mecocci and B. Frei, "Plasma Vitamin C Levels Are Decreased and Correlated With Brain Damage in Patients With Intracranial Hemorrhage or Head Trauma," Stroke, vol. 32, no. 4, pp. 898-902, 2001. [7] K. H. Alzoubi, A. F. Shatnawi, M. A. Al-Qudah and M. A. Alfaqih, " Vitamin C attenuates memory loss induced by post-traumatic stress like behavior in a rat model," Behav Brain Res, 2020. [8] Q. Shen, J. B. Hiebert, J. Hartwell, A. R. Thimmesch and J. D. Pierce, " Systematic Review of Traumatic Brain Injury and the Impact of Antioxidant Therapy on Clinical Outcomes," Worldviews Evid Based Nurs, vol. 13, no. 5, pp. 380-389, 2016.p
Disclaimer: Nucleic products does not take liability or responsibility for any misuse of this informational research material. Information of our products is for educational purposes only and pulled from research journals cited. These products and informational documents are not intended to diagnose, treat or mitigate any disease. This product has not been evaluated by the FDA.
Order Today: To order go to our web site at:
joyfullivingservices.com/nucleic-products.html
Immuno-Modulation
Allergies
Degenerative Conditions
Epinephrine/Dopamine Regulation
Neuronal Antioxidant (Stroke, TBI, Memory)
Vitamin C and Liposomal Technology Vitamin C has multiple beneficial physiological effects. These include antioxidant properties, synthesis of catecholamines, formation of collagen, facilitation of iron absorption, and support with the processing of many hormones, enzymes, and amino acids. In a recent clinical study, it was demonstrated that oral delivery of Liposomal Vitamin C produced circulating concentrations of vitamin C greater than those elicited by oral delivery of Non-Liposomal Vitamin C and has the added ability to cross through the Blood Brain Barrier. [1] [2]
Immuno-Modulation Vitamin C affects various aspects of the immune process. Its high concentration in leukocytes, its rapid utilization during infection, and its depression in clinical situations associated with reduced immunologic function have suggested a role for the vitamin in the immune response. There is evidence that Vitamin C is involved in several neutrophil functions, including chemotactic responses, phagocytosis, hexose monophosphate shunt activity, myeloperoxidase function, and cyclic GMP levels. [3]
Degenerative Conditions Research suggests that high-dose vitamin C kills degenerative cells. New studies show some degenerative cells with low levels of catalase enzyme activity are much less capable of removing hydrogen peroxide formed by vitamin C, than normal cells, and are more susceptible to damage and death when they are exposed to high doses of vitamin C. [4]
Norepinephrine/Dopamine Regulation Vitamin C functions as a neuromodulator for dopamine and norepinephrine. A deficiency of Vitamin C is associated with significant increases in dopamine levels and similar relative decreases in norepinephrine because normal amounts of dopamine could not be metabolized into norepinephrine. Liposomal Vitamin C is capable of crossing the blood-brain barrier to regulate dopamine and nor-epinephrine levels. [5]
Neuronal antioxidant support Studies show Vitamin C is a vital antioxidant. Vitamin c has shown promise in its high antioxidant role against ischemic stroke, Alzheimer's disease, Parkinson's disease, and Huntingdon's disease. [5]
Stroke Several studies found that a low vitamin C status in humans is associated with increased mortality rates from stroke, and plasma Vitamin C concentrations are decreased in stroke and critically ill patients. This data on antioxidant depletion suggests that there is significant oxidative stress associated with brain injury. [6]
Post Traumatic Stress Disorder (PTSD) Oxidative stress is linked with many psychiatric conditions including PTSD. Vitamin C has successfully attenuated memory impairment and all changes observed in oxidative stress markers induced by PTSD. [7]
Traumatic brain injury (TBI) TBI is an acquired brain injury that occurs when there is sudden trauma that leads to brain damage. There is evidence that a secondary injury from TBI is specifically related to oxidative stress. By incorporating antioxidant support with Vitamin C, clinicians can help attenuate oxidative posttraumatic brain damage and optimize patients' recovery. [8]
Memory In a recent study vitamin C administration successfully attenuated memory impairment and all of the changes observed in oxidative stress markers. Oxidative stress is associated with neuronal damage in many brain regions including the hippocampus; an area in the brain responsible for memory processing. [7]
Ingredients: Ascorbate Acid (Vitamin C), Sodium Ascorbate, Potassium Sorbate, Stevia Leaf Extract (as Glucosylsteviosides), Natural Flavors, Glycerin, Non-GMO Sunflower Lecithin, Purified Water.
Sources: [1] J. L. Davis, H. L. Paris, J. W. Beals, S. E. Binns, G. R. Giordano, R. L. Scalzo, M. M. Schweder, E. Blair and C. Bell, "Liposomal-encapsulated Ascorbic Acid: Influence on Vitamin C Bioavailability and Capacity to Protect Against Ischemia–Reperfusion Injury," Nutr Metab Insights, vol. 9, pp. 25-30, 2016. [2] "Vitamin C Shown To Cross The Blood Brain Barrier," Memorial Sloan-Kettering Cancer Center, 6 December 1997, sciencedaily.com/releases/1997/12/971206133607.htm. [Accessed 10 May 2022]. [3] B. V. Siegel, "Vitamin C and the Immune Response in Health and Disease," Nutrition and Immunology, pp. 167-196, 1993. [4] C. M. Doskey, V. Buranasudja, B. A. Wagner, J. G. Wilkes, J. Du, J. J. Cullen and G. R. Buettner, "Why high-dose vitamin C kills cancer cells: Low levels of catalase enzyme make cancer cells vulnerable to high-dose vitamin C.," Redox Biology, vol. 10, no. 274, 2016. [5] F. E. Harrison and J. M. May, "Vitamin C Function in the Brain: Vital Role of the Ascorbate Transporter (SVCT2)," Free Radic Biol Med, vol. 46, no. 6, pp. 719-730, 2009. [6] M. C. Polidori, P. Mecocci and B. Frei, "Plasma Vitamin C Levels Are Decreased and Correlated With Brain Damage in Patients With Intracranial Hemorrhage or Head Trauma," Stroke, vol. 32, no. 4, pp. 898-902, 2001. [7] K. H. Alzoubi, A. F. Shatnawi, M. A. Al-Qudah and M. A. Alfaqih, " Vitamin C attenuates memory loss induced by post-traumatic stress like behavior in a rat model," Behav Brain Res, 2020. [8] Q. Shen, J. B. Hiebert, J. Hartwell, A. R. Thimmesch and J. D. Pierce, " Systematic Review of Traumatic Brain Injury and the Impact of Antioxidant Therapy on Clinical Outcomes," Worldviews Evid Based Nurs, vol. 13, no. 5, pp. 380-389, 2016.p
Disclaimer: Nucleic products does not take liability or responsibility for any misuse of this informational research material. Information of our products is for educational purposes only and pulled from research journals cited. These products and informational documents are not intended to diagnose, treat or mitigate any disease. This product has not been evaluated by the FDA.
Order Today: To order go to our web site at:
joyfullivingservices.com/nucleic-products.html
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