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MTHFR Gene Mutations

3/6/2022

1 Comment

 
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​Two years ago I attended the IIPA Annual Symposium and I had the privilege to hear Dr. Michael Salas, ND speak about MTHFR.  At that time I didn’t know anything about MTHFR but Dr. Salas peaked my interest.  After his talk I was convinced I wanted to learn more about MTHFR and wanted to work with him to help improve the lives of myself, my family, my clients, and anyone who would be interested in listening to me.
 
At that time I found out that Dr. Salas had done enough studies on patients with brown pigments to show that when someone has a brown pigment in their iris that they have this gene mutation.  He proved this theory by looking at the irises and then confirmed with blood tests from a reputable lab.
 
This intrigued me because I have both brown and orange pigments in my eyes and many of my clients have not only brown and orange but also yellow pigments.  I was curious what could be connected to the orange and yellow pigments as well.  I therefore decided to conduct an IIPA approved 6-month peer review to continue to prove that the brown pigments are linked to the MTHFR gene mutations.  Amazingly, I’ve found that the orange pigments in both the blue-eyed people and the mixed-biliary eyed people are also connected to the MTHFR gene mutation.  So far all my clients who have had brown and orange pigments have been positive for MTHFR gene mutations based on blood tests. 
 
Since this time I have found out that 70% of the US population have MTHFR gene mutations.  It makes me wonder why doctors do not perform regular blood tests for this since it is making such a huge impact in people’s health.

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Signs in the Iris of the Eye
These pictures are of my irises.  When I learned about iridology back in 1989 from Dr. Bernard Jensen, he told me I had blue eyes and if I cleansed my body my eyes would turn blue.  I can’t count how many bowel, liver, gallbladder, parasite, and blood cleanses I’ve done and my eyes are still the same today as they were 32 years ago.  Now of course with the research we know that my eyes are a mixed-biliary constitution and they will never change.  I will always have to work with my digestive system which is why I was interested in iridology in the first place.

There are a lot of cardio issues on both sides of my family including heart attacks, strokes, aortic and abdominal aneurysms, high cholesterol, high triglycerides, high blood pressure, fatty liver, high LDL, and low HDL among other things.  Personally, I first noticed issues when I was pregnant with my daughter 21 years ago as I was diagnosed with preeclampsia.  I had high blood pressure, swelling, and low platelets when I was pregnant with her.  The doctors had to monitor me very closely and finally induced me because my blood pressure was 200/110 and would not go down to normal.  My family also has a history of diabetes and I have been diagnosed with metabolic syndrome.  In working with doctors, I found they just wanted to put me on beta blockers to control the blood pressure and did not try to find out the cause.  Luckily for me, I had side effects to the beta blockers and had to stop them.  I saw a cardiologist for testing because my blood pressure would not come down after giving birth to my daughter and I wanted to have another child in a couple of years.  The cardiologist gave me 3 months to bring my numbers back to normal or she said she would put me back on medication.  I was able to bring my cholesterol and triglycerides back into normal range after changing my diet and going to the gym.  I was also able to maintain a healthy blood pressure due to the cardio workout program I was on and the low sodium diet.  However, the problem has persisted all these years.  

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​After learning about MTHFR I was curious to find out if the metabolic syndrome was connected to all my cardio issues and infertility issues.  I wanted to learn “why” I have metabolic syndrome and went to see a Functional Doctor in our medical group.  She ran many tests and found so many issues.  At that point I also found out (because of Michael Salas) that I have 2 C677T gene mutations (one from my mother’s side of the family and one from my father’s side of the family) so I am at a higher cardio risk which makes sense because all my relatives in Italy have had heart attacks and strokes. 
 
Because of the results of these tests I have my answers to “why” I have metabolic syndrome and I know what to do about it.  I don’t have to live my life worrying about my health and if I’m going to end up with cardio problems like my family has suffered with. I have been working differently with my body to help my liver methylate.  I have known something has been out of balance all these years but no one has suggested anything to me about MTHFR until I met Michael Salas and no one has offered to help me figure out the cause.  I found out that my lecithin was very high, my homocysteine levels are very high, all my cardio risk tests are high and my liver panel was out of balance.  Now that I know I have this gene mutation I can take responsibility and work on helping my liver methylate.  This also helps all my clients.  Since I’ve opened my office I’ve seen 13 new clients and every single one of them has had either brown, orange, or brown and orange pigments in their irises.  I have sent them all for MTHFR testing and am waiting for the results.
 
My Personal Supplementation Program
Once I found out I had high homocysteine levels I started working with:
  • Omega 3
  • Red Rice Yeast
  • CoQ10
  • Berberine
  • Methylzyme – helps the liver methylate
 
Once I was on these products for 3 months I had another blood test and my levels normalized.  My numbers are better than they have been in 10 years.

Let’s Talk About MTHFR
If you don’t know what MTHFR means you are not alone.  Most people have never heard about it.  Most people don’t know they have a gene mutation unless they have severe symptoms or undergo genetic testing.  Doctors don’t mention it at all when you see them for an annual physical or if you have a problem.  They don’t order any blood tests to check for MTHFR either.  So what is it?
 
MTHFR stands for Methylenetetrahydrofolate Reductase which is an enzyme that breaks down the amino acid homocysteine. The MTHFR gene that codes for this enzyme has the potential to mutate, which can either interfere with the enzyme's ability to function normally or completely inactivate it.

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​MTHFR Genes C677T and A1298C
People have two MTHFR genes, inheriting one from each of their parents. Mutations can affect one (heterozygous) or both (homozygous) of these genes.  There are two common types, or variants, of MTHFR mutation: C677T and A1298C.  Mutations in the MTHFR gene can affect the body’s ability to process amino acids — namely homocysteine — which can lead to health conditions.

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Homocysteine
Having one or two MTHFR mutations can increase the levels of homocysteine in the blood. This condition is called homocystinemia.
 
Homocysteine is an amino acid that the body produces by breaking down dietary proteins. High levels of homocysteine can damage blood vessels and lead to blood clots. People who have high homocysteine levels tend to have low levels of vitamin B-12.
 
Symptoms of homocystinemia due to MTHFR mutations include:
  • abnormal blood clotting
  • developmental delays
  • seizures
  • microcephaly
  • blood clots
  • poor coordination
  • numbness or tingling in the hands and feet
 
Health Conditions Associated with MTHFR Gene Mutations
  • Homocystinemia: abnormally high levels of homocysteine in the blood or urine
  • Ataxia: neurological condition that affects coordination
  • peripheral neuropathy: neurological condition that damages the nerves
  • microcephaly: condition present at birth in which the head is smaller than usual
  • scoliosis: abnormal curvature of the spine
  • anemia: lack of healthy red blood cells
  • cardiovascular diseases such as blood clots, strokes, and heart attacks
  • mental health and behavior disorders: depression and attention deficit hyperactivity disorder (ADHD)

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Brown and Orange Pigments
During my studies I have repeatedly found that brown pigments are linked to the C677T gene mutation and the orange pigments are linked to the A1298C gene mutation.  It doesn’t seem to matter how old the client is, if they’ve been vaccinated, what they eat, drink, or where they live.  Most of these clients have health issues that are unresolved and are either on medications or are looking for answers the medical profession has not been able to answer.  Some have told me that the doctors have said they are fine when they are not fine.
 
In working with clients I have them fill out my client intake form to learn about their current and past health issues and symptoms and I have them take the MTHFR gene test through a reputable lab either by blood or by saliva.  So far everyone I have tested with pigments has come back positive for the MTHFR gene errors. 
 
Pregnancy
“Women who test positive for an MTHFR mutation may have an increased risk of preeclampsia, blood clots, recurrent miscarriages, or giving birth to a baby with congenital disabilities.”  I had preeclampsia with my daughter.  When I gave birth to her my blood pressure was 200/110, my cholesterol was over 500, and my triglycerides were over 1,000.  My daughter has a mixed-biliary iris like I do and has the same health issues I have.  We have ordered the MTHFR blood test for her and are anxious to find out if she has the MTHFR gene errors as well.
 
References:
Medical News Today
Aquaporin Channels Video:  https://youtu.be/L1TyWo86w4Q
Microbiologic Concepts of Genomic Iridology Video by Dr. Michael SalasPMC Articles: 
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4644301/
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5492960/
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262611/

1 Comment
Teresa May (MEW) link
5/24/2022 02:49:02

You may have observed the abbreviation MTHFR pop up in current health news. It mentions to a comparatively usual genetic mutation. MTHFR stands for methylene tetra hydro folate reductase. It’s acquiring focus due to a genetic mutation that may affect high levels of homocysteine in the blood and low levels of folate and other vitamins. Its key function is to offer your body with guidelines in building up the MTHFR protein, which aids your body, creates folate. This B vitamin is important to build up DNA. There’s been impact on those specific health problems which are connected with MTHFR mutations, so examining has become more accepted over the years. Gene mutations are inborn, which means you get them from your parents.

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